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AI and Machine Learning

AI is the new electricity and will transform every aspect of our lives. The achievement of AlphaGo and AlphaFold are just two notable examples. Machine learning, a branch of AI, has transformed how mammograms and pathology slides are examined in clinical practice. We are combining synthetic biology with bioinformatics and machine learning to identify ideal targetable disease signatures, explore a vast circuit design space, and reliably predict circuit performance. We are developing various deep neural network algorithms and generative models to extract meaningful insights from complex biomedical datasets and to create de-novo genomic sequences for gene therapy applications (Fig. 1). We envision that by combining the best of the three domains, we will make a breakthrough impact in genetic engineering.

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